Pharmacological properties: belongs to the group of antiemetic agents. The active substance - maropitant citrate - is an antagonist of neurokinin receptors (NK1) and inhibits the binding of substance P, neurokinin A, and neurokinin B in the CNS.
Maropitant citrate is effective in vomiting of both central and peripheral origin. Maropitant is rapidly absorbed from the injection site and reaches maximum plasma concentration 45 minutes after administration.
Maropitant is more than 99% bound to plasma proteins. The bioavailability of Serenia is 90%. Maropitant is metabolized in the liver by cytochrome P450 and is mainly excreted in the feces.
